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Tofranil (generic name: Imipramine; brand names include: Antideprin / Deprenil / Deprimin / Deprinol / Depsonil / Dynaprin / Eupramin / Imipramil / Irmin / Janimine / Melipramin / Surplix / Antidep / Apo-Imipramine / Chrytemin / Daypress / Depsol / Ethipramine / Fronil / Imidol / Imimine / Imine / Imiprex / Imiprin / Impril / Medipramine / Melipramine / Mipralin / Novopramine / Primonil / Pryleugan / Sermonil / Sipramine / Talpramin / Tofnil / Tofranil-PM / Venefon) belongs to a group of medicines known as tricyclic antidepressants.

Tofranil is used for the treatment of depression including endogenous, organic and psychogenic forms, and depression associated with personality disorders or chronic alcoholism.

Tofranil may also be used to treat bedwetting (enuresis) in children (5 years and older).
Recommendations

Follow the directions for using this medicine provided by your doctor. Take Tofranil exactly as directed.

Depression and depressive syndromes

Adults

Start treatment with 25 mg 1-3 times daily. Raise the daily dosage gradually to 150-200 mg. This dosage should be reached by the end of the first week and maintained to this dose until a clear improvement is seen. The maintenance dose, which must be individually determined by cautiously reducing the dosage, is usually 50-100 mg daily.

Elderly patients

Start treatment with 1 tablet of 10 mg daily. Gradually raise the dosage to 30-50 mg daily (optimum level), which should be reached after about 10 days and then maintained until the end of treatment.

Childhood Enuresis

Initially, an oral dose of 25 mg/day should be tried in children aged 5 and older. Medication should be given one hour before bedtime. If a satisfactory response does not occur within one week, increase the dose to 50 mg nightly in children under 12 years; children over 12 may receive up to 75 mg nightly. A daily dose greater than 75 mg does not enhance efficacy and tends to increase side effects. Evidence suggests that in early night bedwetters, the drug is more effective given earlier and in divided amounts, i.e., 25 mg in midafternoon, repeated at bedtime. Consideration should be given to instituting a drug-free period following an adequate therapeutic trial with a favorable response. Dosage should be tapered off gradually rather than abruptly discontinued.
Precautions

Tell your doctor before taking Tofranil, if:

you are allergic to any medicines;
you have any serious medical conditions;
you are pregnant or breast-feeding.
Ingredients

Active ingredient: imipramine.
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