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Mysoline is used alone or with other medications for treating grand mal, psychomotor, or focal epileptic seizures. It may be effective for grand mal seizures that are not responsive to other anticonvulsants. Primidone should not be used by patients with porphyria and people who are allergic to phenobarbital.

SIDE EFFECTS:

Common side effects of primidone include:

Difficulty speaking (dysarthria)
Burning, tingling from damaged nerves (paresthesia)
Difficulty moving (ataxia)
Loss of balance (vertigo)
Paradoxical excitement (children)
Hyperactivity (children)
Excitement
Confusion
Depression
Drowsiness
Irritability
Headache
Restlessness
Nystagmus
Dizziness

Possible serious side effects of primidone include:

Acute psychosis
Nausea
Vomiting
Constipation
Diarrhea
Folate-deficiency anemia
Liver toxicity
Low blood calcium
Rickets
Weakening of bones
Rash
Serious skin reactions (for example, Stevens-Johnson syndrome)

Seizure medications increase the risk of suicidal thoughts or behavior. Patients treated with seizure medications should be observed for the emergence or worsening of depression, suicidal thoughts or behavior, and unusual changes in mood or behavior.

Suddenly stopping medications for seizures may cause seizures.

PREPARATIONS: Tablets: 50 and 250 mg

DRUG INTERACTIONS: Primidone may decrease blood levels and the effect of several drugs by increasing the activity of liver enzymes that breakdown these drugs. Examples of drugs affected by Primidone include naloxegol (Movantik), roflumilast (Daliresp), lurasidone (Latuda), and many others.

PREGNANCY AND BREASTFEEDING SAFETY: Primidone has not been adequately evaluated in pregnant women. Some other seizure medications have been associated with birth defects. Primidone is excreted in human milk and may cause adverse effects in the infant.

STORAGE: Primidone should be stored at room temperature, 20 C - 25 C (68 F - 77 F).

DOSING:

Patients 8 years of age or older should be treated with the following regimen:
Days 1 to 3: 100 to 125 mg at bedtime.
Days 4 to 6: 100 to 125 mg twice daily.
Days 7 to 9: 100 to 125 mg three times daily.
Day 10 to maintenance: 250 mg three or four times daily.
The maximum dose is 2 g daily.
It takes several weeks before the antiseizure effects of primidone are seen.

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